9239967871ENSG00000148187ENSMUSG00000026887Q96E11Q9D6S7NM_001346341NM_001346343NM_001346345NM_001346347NM_026422NP_001333276NP_620132NP_954646NP_080698Ribosome recycling factor or ribosome release factor (RRF) is a protein found in bacterial cells as well as eukaryotic organelles, specifically mitochondria and chloroplasts.
It functions to recycle ribosomes after completion of protein synthesis (bacterial translation).
The ribosome recycling factor was discovered in the early 1970s by the work of Akira Kaji and Akikazu Hiroshima at the University of Pennsylvania.
[5][6][7][8] Their work described the requirement for two protein factors to release ribosomes from mRNA.
[13] The most striking revelation was that RRF is a near-perfect structural mimic of tRNA, in both size and dimensions.