Parts of the Rio Negro Right Bank Environmental Protection Area lies in the municipalities of Iranduba (21.17%), Manacapuru (18.96%) and Novo Airão (59.87%) in the state of Amazonas.

It does not include the section of the right bank covered by the Rio Negro Sustainable Development Reserve, or the surroundings of the town of Novo Airão.

In the section north of Novo Airão the forests are almost intact, but further south there are degraded areas in the municipality of Iranduba due to the proximity of Manaus.

There are more than 300 species of birds, including the endangered black-and-white hawk-eagle (Spizaetus melanoleucus) and harpy eagle (Harpia harpyja).

The APA is home to many species of frogs, lizards and snakes, and several of turtles and alligators, including the endangered black caiman (Melanosuchus niger).