Her research explores the pathogenesis of neuroinflammation in the central nervous system by probing how immune signalling molecules regulate blood brain barrier permeability.

[8] She is the co-director of the Amgen Scholars Program at Washington University ensuring that a diverse group of undergraduate students have the opportunity to experience science in top labs.

[11] Klein reports that “naming the problem is the first step in solving it”, suggesting that conducting quantitative studies on gender bias in scientific meetings, hiring, acceptances, grant awards etc.

[11] Research in the Klein Lab is focused on exploring the cellular and molecular mechanisms that orchestrate inflammation and mediate its effect on the central nervous system.

[12] For example, since West Nile Virus has been shown to cause significant brain damage leading to memory loss, Klein’s lab researches ways to prevent this from occurring.

[13] These findings signify increased neuronal pruning and destruction by microglia leading to memory loss in patients with West Nile Virus infections.

Her lab specifically explores the cues that drive the localization, proliferation, and differentiation of neural stem cells to mediate their ability to successfully repair damaged neurons and myelin.

[15][16] Since demyelinating diseases are a focus of the lab, Klein made a discovery in 2014, that multiple sclerosis (MS) disproportionally effects women compared to men due to higher expression of a blood vessel receptor protein S1PR2.