The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase.

[8] Within the fat (adipose) tissue of CCR2 deficient mice, there is an increased number of eosinophils, greater alternative macrophage activation, and a propensity towards type 2 cytokine expression.

As a consequence when an acute ischemic event happens during the active phase, monocytes are more susceptible to invade the heart.

[10] An excessive monocytes infiltration generates higher inflammation and increases the risk of heart failure.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.