Rock Creek is a 56-mile (90 km) intermittent stream flowing in Lake and Harney counties in the U.S. state of Oregon.

The creek passes by Antelope Hot Springs downstream of the campground.

Further downstream, it flows through the refuge headquarters, where it passes under Frenchglen Road.

The creek then runs roughly parallel to Poker Jim Ridge, on the left, before heading east into Rock Creek Reservoir and then into Catlow Valley.

[5] Catlow Valley is a closed basin, with no outlet to the sea.