Rufino is a city in the province of Santa Fe, Argentina.

It lies on the southwest of the province, 260 km (162 mi) from the main metropolitan area of the province Greater Rosario,416 km (258 mi) from the provincial capital Santa Fe, near the borders with Córdoba (west) and Buenos Aires (south), on the intersection of National Routes 33 and 7.

The town was founded by Gerónimo Segundo Rufino in 1886, as the railway line that linked Diego de Alvear, Santa Fe, to Villa Mercedes, San Luis, was inaugurated.

The plans for the new town were approved by the governorship of Santa Fe on 29 March 1889, which is acknowledged as the official foundation date.

This article about a place in Santa Fe Province, Argentina is a stub.