Rustrel (French pronunciation: [ʁystʁɛl]; Occitan: Rustrèu) is a commune in the Vaucluse department in the Provence-Alpes-Côte d'Azur region of Southeastern France.

In 2017, it had a population of 688.

This village is famous for its ochre, which many people come to visit in the French Colorado.

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