SH3D21

[5] The human mRNA transcript is 2527 base pairs and the final protein product is 756 amino acids.

[6] While the exact function of this protein remains unknown, due to the presence of three SH3 domains, it has been implicated in protein-protein interactions.

In humans, these SH3 domains have a common amino acid sequence Asp-Glu-Leu.

[19][20] Further studies have implicated the chromosomal region of 1p34.3 in Intracranial Aneurysm and as a negative prognosis sign in colorectal cancer.

BLAST analysis found distant orthologs in Osteichthyes with a max identity of 28%.

This image is a multiple sequence alignment of the three SH3 domains found in the human SH3D21 protein. Note the conserved Asp-Glu-Leu motif. This image was generated using publicly available sequence data and open source software.
Phylogenetic tree generated using open source, free software and publicly available sequence data.