SHIRPA is a standardized set of experimental procedures used by scientists to characterize the phenotype of genetically modified laboratory mice.
[1] SHIRPA is an acronym of SmithKline Beecham, Harwell, Imperial College, Royal London Hospital, phenotype assessment), proposed in 1997 by a group of researchers from a number of British institutions and the pharmaceutical company, SmithKline Beecham.
The third screening stage is focused on potential animal models of neurological disease.
[9] The first part of the SHIRPA protocol was changed to include observations on morphology and dysmorphology.
This protocol became known as the "modified SHIRPA" and has been used to screen for dominant phenotypes in mice.