Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis.

The encoded protein may play a role in breast cancer proliferation and chemoresistance.

Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

[5][6] The researchers also found that the expression of sphingosine kinase 2 (SphK2) and the secretion of sphingosine-1-phosphate (S1P) were significantly upregulated in the lungs of CS-exposed mice with COPD-like symptoms.

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