1UKL672120788ENSG00000198911ENSMUSG00000022463Q12772Q3U1N2NM_004599NM_033218NP_004590NP_150087Sterol regulatory element-binding protein 2 (SREBP-2) also known as sterol regulatory element binding transcription factor 2 (SREBF2) is a protein that in humans is encoded by the SREBF2 gene.

[5] This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes.

The encoded protein contains a basic helix-loop-helix leucine zipper (bHLH-Zip) domain.

[6] Various single nucleotide polymorphisms (SNPs) of the SREBF2 have been identified and some of them are found to be associated with higher risk of knee osteoarthritis.

[10] This article incorporates text from the United States National Library of Medicine, which is in the public domain.