McCluer South-Berkeley High School is a grade 9-12 secondary school located at 201 Brotherton Lane in the city of Ferguson, Missouri.

Located in the Ferguson-Florissant School District (FFSD), McCluer South Berkeley is the newest secondary school.

The school opened in January 2004, replacing Berkeley High School in Berkeley, which had closed in December 2003 due to expansion of the Lambert-St. Louis International Airport.

[2] When it was a zoned school, MSB educated students from the cities of Cool Valley, Ferguson, Kinloch and Berkeley.

[citation needed] As of October 10, 2018 The Board Of Education has decided to convert MSB into a STEAM school.