Saeed Ghani Khaskheli (Urdu: سعید غنی خاصخیلی; born 8 July 1972) is a Pakistani politician who served as the Provincial Minister of Sindh for Labour and Information and Human Resources.

[5] He was elected to the Provincial Assembly of Sindh as candidate of PPP from Constituency PS-114 (Karachi-XXVI) in by-polls held in July 2017.

[6][7] He was re-elected to the Provincial Assembly of Sindh as a candidate of PPP from Constituency PS-104 (Karachi East-VI) in the 2018 Pakistani general election.

[8] On 19 August, he was inducted into the provincial Sindh cabinet of Chief Minister Syed Murad Ali Shah and was made Provincial Minister of Sindh for Local Government with the additional ministerial portfolios of Public Health Engineering and Rural Development, and Katchi Abadies.

[9] On 5 August 2019, he was appointed as Provincial Minister of Sindh for Labour, Information and Archive.