It flows in the municipalities of Saint-Sylvestre and Sainte-Agathe-de-Lotbinière, in the Lotbinière Regional County Municipality, in the administrative region of Chaudière-Appalaches, in Québec, in Canada.

The main neighboring watersheds of the Saint-André river are: The Saint-André River has its source in the municipality of Saint-Sylvestre, at 0.6 kilometres (0.37 mi) east of the village center.

This headland is located south of route 216, north of Mont Handkerchief and south of the village of Saint-Patrice-de-Beaurivage.

From its source, the Saint-André River flows over 12.5 kilometres (7.8 mi) divided into the following segments: The Saint-André river empties on the south bank of the Filkars River in the eastern part of the territory of Sainte-Agathe-de-Lotbinière.

The toponym "rivière Saint-André" was formalized on December 5, 1968, at the Commission de toponymie du Québec.