Saint-Roman-de-Malegarde (French pronunciation: [sɛ̃ ʁɔmɑ̃ də malɡaʁd]; Occitan: Sant Roman de Malagarda) is a commune in the Vaucluse department in the Provence-Alpes-Côte d'Azur region in southeastern France.

On the edge of the Vaucluse, looking onto the border with the Drôme and dozing between Bollène and Vaison-la-Romaine, Saint-Romain-de-Malegarde is a former outpost of the order of the Knights Templar, built on the left bank of the Aygues on the northern border of the Comtat Venaissin.

The top of the old village is built on a hill, where the streets are steep and narrow.

The bottom of the village has absorbed new buildings such as the school and the mairie (town hall).

Most of the inhabitants are wine-growers and cultivate appellation d'origine contrôlée (AOC) Côtes du Rhône vineyards.