A committee was formed, and eventually, the cornerstone was founded on Friday, June 16, 1922, under the papacy of Pope Cyril V. Prayers were held in a temporary location and started in January 1925.

Ibrahim Luke served as the first priest, and was at St. Mark's Church until he died in 1950.

Today, there are nineteen priests that serve Saint Mark's Church alone.

It was opened by Pope Cyril VI on June 5, 1964, and the new altar was consecrated, bearing the name of Saint Menas.

[5] As Saint Mark's Church has had a long history, there were several occasions upon which there were Papal visits made by different Coptic Popes.