Samtsevrisi Castle is a large medieval Georgian castle or fortress in the village of Samtsevrisi, Kareli Municipality, in Georgia's region of Shida Kartli.

Presumably, it belonged to noble Panaskerteli-Tsisishvili ancestors, who settled here in the 15th century.

Archeological discoveries on the place revealed large amount of ceramic fragments, dating from the beginning of the 2nd millennium B.C.

The large tower of the castle was built in the early medieval period.

The castle garrison was homed in its northern part, separated from the southern citadel.