[2] After the death of his father around 1802, Wilkeson moved to Mahoning County, Ohio, where he built a farm and the first grist mill in the area.

[3] During the War of 1812, Wilkeson was asked to build a fleet of ships for the U.S. Army at Buffalo, brought his family there, and opened a general store.

[5] In 1823, Samuel Wilkeson was elected to the New York State Assembly as a People's Party candidate serving from January 1, 1824, to December 31, 1824, when he was succeeded by Calvin Fillmore.

[6] In 1824, he was elected as a Clintonian (supporters of DeWitt Clinton, opposed to the Bucktails) to the New York State Senate, serving until 1829 in one of the four seats in the 8th district, which consisted of Allegany, Cattaraugus, Chautauqua, Erie, Genesee, Livingston, Monroe, Niagara, and Steuben counties.

They later moved to Buffalo where his father built the Wilkeson Mansion in 1824, across Lafayette Square from the home of his close friend, President Millard Fillmore.