San Francisco de Asis is a town within the municipality of the Atotonilco El Alto located in the southeastern part of the state of Jalisco in Mexico.

Its most distinctive features are the Fine Sanctuary of Our Lady of Los Altos and the fact that new tequila factories are located there.

Its surrounding municipality of the same name had an area of 1,532.78 km² (591.81 sq mi) and a population in conjunction of Atotonilco el Alto of 126,625 in the 2005 census, but its territory has increased significantly since the beginning of 2005 with the creation of the new housing, churches, and schools.

Traditionally, the region of San Francisco de Asis is known for its inhabitants of French, German, Italian, Fenicia and Spanish ancestry strong family and Roman Catholic values.

A traditional Sunday night consists of many going to church and either going to visit nearby relatives or heading to eat with a group of friends or family.