San Gregorio di Catania (Sicilian: San Grigoriu) is a comune (municipality) in the Metropolitan City of Catania in the Italian region Sicily, located about 170 kilometres (110 mi) southeast of Palermo and about 7 kilometres (4 mi) northeast of Catania.

San Gregorio di Catania borders the following municipalities: Aci Castello, Catania, San Giovanni la Punta, Tremestieri Etneo, Valverde.

At that time the "Giurati" or "Jury" was replaced with the "Decurionato", a group ten men elected by common people and approved by the king.

After Italian unification, in 1860, the "Decurionato" was also abolished and replaced by a modern administrative system.

San Gregorio took its name from its patron saint, Pope Gregory I.