Zafferana Etnea (Italian pronunciation: [dzaffeˈraːna etˈnɛːa]; Sicilian: Zafarana [tsafaˈɾaːna]) is a comune (municipality) in the Metropolitan City of Catania in the Italian region Sicily, located about 160 kilometres (99 mi) southeast of Palermo and about 20 kilometres (12 mi) north of Catania.

The municipality of Zafferana Etnea contains the frazioni (subdivisions, mainly villages and hamlets) Fleri, Pisano, Petrulli; Sarro-Civita, Passopomo, Airone-Emmaus, Poggiofelice, and Caselle.

Zafferana Etnea borders the following municipalities: Aci Sant'Antonio, Acireale, Adrano, Belpasso, Biancavilla, Bronte, Castiglione di Sicilia, Giarre, Maletto, Milo, Nicolosi, Pedara, Randazzo, Sant'Alfio, Santa Venerina, Trecastagni, Viagrande.

It is celebrated every Sunday in October and is an opportunity to partake of local pastries and cakes as well as typical products of the city such as grapes, bottled fruit, mushrooms, honey, liquor, wine, and chestnuts.

Zafferana, along with Nicolosi, is now regarded as a major tourist stopping point for summer and winter expeditions to the summit of Mt.