Saint Alphius (in Italian: Sant'Alfio) or (Sicilian: Sant'Arfiu) is a comune (municipality) in the Metropolitan City of Catania in the Italian region Sicily, about 160 kilometres (99 mi) east of Palermo and about 25 kilometres (16 mi) north of Catania.

Saint Alphius borders the following municipalities: Adrano, Belpasso, Biancavilla, Bronte, Castiglione di Sicilia, Giarre, Linguaglossa, Maletto, Mascali, Milo, Nicolosi, Piedimonte Etneo, Randazzo, Zafferana Etnea.

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