San Isidro Buensuceso or San Isidro Buen Suceso is a town in the municipality of San Pablo del Monte, Tlaxcala, Mexico, on the southern slope of La Malinche volcano.

The town is named after Saint Isidore the Laborer (Spanish: San Isidro Labrador), whose feast day is celebrated on May 15 each year.

The people of San Isidro Buensuceso are indigenous Nahuas; the first language of children is Nahuatl.

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