It is part of the public healthcare network in the western portion of Santiago Metropolitan Region, providing health services to residents of Santiago, Quinta Normal, Lo Prado, Renca, Cerro Navia and Pudahuel within the borders of the city.

It also provide healthcare to patients from the Melipilla Province, including Melipilla, Alhué, Curacaví, María Pinto and San Pedro; as well as the Talagante Province, which includes the municipalities of Isla de Maipo, El Monte, Padre Hurtado, Peñaflor and Talagante.

[1] The hospital complex consists of four buildings: the main tower, the Centro Diagnóstico y Terapéutico (CDT) Prof. Dr. Rodolfo Armas Cruz, the Ex Posta 3 and the Centro de Diabetes y Nutrición Helen Lee Lassen.

Its original location was on the south side of the Alameda, just across the street from the Iglesia San Francisco.

Following the demolition of the old building in 1944, the San Juan de Dios Hospital was relocated, rebuilt and reopened on May 1, 1954.