San Lorenzo, Sansepolcro

San Lorenzo is a Renaissance-style, Roman Catholic church located on Via Santa Croce 2 corner with Via Luca Pacioli, in Sansepolcro, province of Arezzo, region of Tuscany, Italy.

The church was suppressed in the 19th century, and for many years used as a part of an orphanage, where the children learned how to weave textiles.

Another canvas in the church depicted San Benedetto by Giovanni Battista Mercati.

The recent events in Rome likely contributed to the painting's dark and turbulent assembly, relative to the painter's prior depiction of the same subject in his Volterra masterpiece.

The Sansepolcro Deposition depicts a mob surrounding a cadaverous Christ and his grieving mother, including monstruous or hooded faces in the background; the Volterra painting is more intimate and depicts those struggling with physically lowering the delicate corpse, in addition to those struggling with the emotional impact of the death.