San Luis al Medio is a village in the Rocha Department of southeastern Uruguay.

The village is located on Route 19, about 29 kilometres (18 mi) west-northwest of Chuy.

The river Río San Luis flows north and west of the town.

On 3 November 1952, its status was elevated to "Pueblo" (village) by the Act of Ley Nº 11.876.

[1] In 2011 San Luis al Medio had a population of 598.