San Marcos is a town and municipality, in Jalisco in central-western Mexico.

In 1542 San Marcos was visited by the Viceroy D. Antonio de Mendoza on his way to put down a large indigenous rebellion.

The town itself was founded on June 28, 1740, by Fray Antonio de Jesus who was instrumental in construction of the church.

In the early 1900s, during the rule of Mexican dictator Porfirio Diaz, the Mexican government forcibly marched thousands of Yaquis some 200 miles over the mountains from San Blas to San Marcos and its train station.

[3] There, the Yaqui survivors were sold at sixty pesos a head to the owners of sugar cane plantations in Oaxaca and the tobacco planters of the Valle Nacional, while thousands more were sold to the henequen plantation owners of the Yucatán.