The Iglesia Parroquial Mayor del Espíritu Santo is located two blocks south of the town's main square; it is a venerable green-towered church whose early 16th-century origins make it the country's oldest.

There is a gorgeous and very Cuban leather sillón fumador (smoking chair) and, in the music room, the mid-18th-century American piano, one of only two of its type in Cuba.

The entire bridge is only 85 meters long and was designed for pedestrians and carriages during colonial-era Cuba but has thus far resisted heavier modern traffic.

The city is crossed in the middle by the Carretera Central (CC), the Cuban principal highway spanning the length of the island.

It counts a railway station on Cabaiguán-Sancti Spíritus-Tunas de Zaza line, with express trains from/to Havana, a terminal for interprovincial omnibuses and an urban bus service.

The local baseball team is the Sancti Spíritus Gallos, and its home ground is José Antonio Huelga Stadium.