Sangre de Cristo Creek is a stream in Costilla County, Colorado.

It starts atop La Veta Pass in the Sangre de Cristo Mountains.

The creek flows alongside Highway 160 as it descends from the top of the pass into the San Luis Valley.

The creek's mouth is at Smith Reservoir, south of Blanca.

In 1879 there was a railroad accident on a grade above the creek, killing one person.