Sans Souci (French for "no worries" or "carefree") is a census-designated place (CDP) in Greenville County, South Carolina, United States.

Sans Souci is bordered to the west by Berea and to the southwest by Parker, both unincorporated communities.

U.S. Route 276 (Poinsett Highway) forms the eastern border of Sans Souci; the highway leads south into Greenville and north 6 miles (10 km) to Travelers Rest.

[5] As of the 2020 United States census, there were 8,581 people, 3,624 households, and 2,033 families residing in the CDP.

31.6% of all households were made up of individuals, and 11.6% had someone living alone who was 65 years of age or older.