In addition to Santa Fe, its district serves parts of League City, La Marque, Hitchcock, and Dickinson.

The high school football team's practice of praying during school-sanctioned sporting events was involved in the court case Santa Fe Independent School District v.

[5] As a result of the mass shooting, the district plans to renovate the northwest area of the campus, including sealing off the art rooms in which the shooting occurred as well as the adjacent hallway.

[7] In July 2018, the district decided to install a bulletproof security area at the main entrance,[7] which included adding metal detectors,[8] as well as adding panic buttons, locks, and alarm systems in classrooms.

[9] As of 2022[update], the school has 1345 students, with the majority being non-Hispanic white and with 24% being classified as low income.