Serotonin pathway

[citation needed] These pathways are relevant to different psychiatric and neurological disorders.

[1][2][3] Given the wide area that the many serotonergic neurons innervate, these pathways are implicated in many functions, as listed above.

The caudal serotonergic nuclei heavily innervate the spinal cord, medulla and cerebellum.

The serotonergic projections into the hypothalamus are thought to be particularly relevant, and an increase in serotonergic signaling is thought to generally decrease food consumption (evidenced by fenfluramine, however, receptor subtypes might make this more nuanced).

Serotonin pathways projecting into the limbic forebrain are also involved in emotional processing, with decreased serotonergic activity resulting in decreased cognition and an emotional bias towards negative stimuli.