The Serpent River is a tributary of the Mégiscane River, flowing into the townships of Trévet, Vasson and Noiseux, in the territory of Senneterre, in La Vallée-de-l'Or Regional County Municipality (RCM), in the administrative region of Abitibi-Témiscamingue, in Quebec, in Canada.

The Serpent River flows entirely in forest area, west of the Gouin Reservoir.

This body of water takes the shape of a snorkel whose blower looks to the east.

The main hydrographic slopes near the Serpent River are: From the mouth of Snake Lake, the Serpent River flows on 41.4 kilometres (25.7 mi) according to the following segments: The Serpent River discharges on the southeastern shore of the Noisy Bay of Canusio Lake, which is crossed to the west by the Mégiscane River, which flows generally towards the west forming large zigzags, until the east shore of Parent Lake (Abitibi).

The toponym "Serpent River" was formalized on December 5, 1968, at the Commission de toponymie du Québec, e.g. at its creation.