In males, Sertoli cell tumours typically present as a testicular mass or firmness, and their presence may be accompanied by gynaecomastia (25%) if they produce oestrogens, or precocious pseudopuberty in young boys, especially if they produce androgens.

[2] On ultrasound, a Sertoli cell tumour appears as a hypoechoic intratesticular lesion which is usually solitary.

[2] Microscopy and immunohistochemistry are the only way to give a definitive diagnosis, especially when there is a suspected seminoma.

[3] In males, due to the difficulty in identifying the tumour using imaging techniques, an orchiectomy is often performed.

[4] Sertoli cell tumors are known to occur in other species, including domestic ducks,[5] dogs,[6][7] and horses.