In enzymology, a serine—tRNA ligase (EC 6.1.1.11) is an enzyme that catalyzes the chemical reaction The 3 substrates of this enzyme are ATP, L-serine, and tRNA(Ser), whereas its 3 products are AMP, diphosphate, and L-seryl-tRNA(Ser).
This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds.
The systematic name of this enzyme class is L-serine:tRNASer ligase (AMP-forming).
This enzyme participates in glycine, serine and threonine metabolism and aminoacyl-trna biosynthesis.
As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes 1SER, 1SES, 1SET, 1SRY, 1WLE, 2CIM, 2CJ9, 2CJA, 2CJB, 2DQ0, 2DQ1, 2DQ2, and 2DQ3.