The Sespe Wilderness is a 219,700-acre (88,900 ha) wilderness area in the eastern Topatopa Mountains and southern Sierra Pelona Mountains, within the Los Padres National Forest (LPNF), in Ventura County, Southern California.

The wilderness was created by the U.S. Congress as part of the Los Padres Condor Range and River Protection Act of 1992 (Public Law 102-301).

The same legislation also established the Chumash, Garcia, Machesna Mountain, Matilija, and Silver Peak Wilderness areas.

[4][5] The Sespe Wilderness is primarily chaparral-covered terrain, with areas of California oak woodland and riparian habitats.

There are hiking trails, perennial and seasonal creeks, waterfalls, hot springs, rock formations, and designated campsites in the wilderness area.