Sewickley Creek is a 29.53 mi (47.52 km) long 4th order tributary to the Youghiogheny River in Westmoreland County, Pennsylvania.

This is the only stream of this name in the United States.

[1] According to the Geographic Names Information System, it has also been known historically as:[1] Sewickley Creek rises in a pond about 1 mile north of Pleasant Unity, Pennsylvania,[2] and then flows westerly to join the Youghiogheny River across from Collinsburg.

[3] Sewickley Creek drains 167.49 square miles (433.8 km2) of area, receives about 43.3 in/year of precipitation, has a wetness index of 370.17, and is about 45% forested.

[5]