Jacks Run is a 9.44 mi (15.19 km) long 3rd order tributary to Sewickley Creek in Westmoreland County, Pennsylvania.

Jacks Run rises about 0.5 miles southwest of Hannastown, Pennsylvania,[2] and then flows southwest to join Sewickley Creek at Youngwood.

[3] Jacks Run drains 28.58 square miles (74.0 km2) of area, receives about 42.2 in/year of precipitation, has a wetness index of 378.89, and is about 34% forested.

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