Township Line Run is a 5.82 mi (9.37 km) long 2nd order tributary to Sewickley Creek in Westmoreland County, Pennsylvania.

[1] Township Line Run rises in Denison, Pennsylvania,[2] and then flows southwest to join Sewickley Creek at Armbrust.

[3] Township Line Run drains 6.49 square miles (16.8 km2) of area, receives about 42.7 in/year of precipitation, has a wetness index of 371.26, and is about 48% forested.

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