In mid-November 2007, the title-character was altered and, by the end of the month, Gerald, May and Gabriella joined the series as main characters, bringing the total to four.

Production began in January 2008 with 40 half-hour episodes (in addition to a special) being ordered for the first season as a two-year on-air commitment.

Reruns of the show later aired on PBS Kids Sprout from March 25, 2013 (the same day as the premiere of the series finale movie) to October 3, 2014.

It was the last PBS show added to Sprout's lineup before NBCUniversal (via its acquisition by Comcast) took full ownership of the network in November 2013.

The main character in the show is Sid, an "inquisitive youngster" who uses comedy to tackle questions kids have about basic scientific principles and why things work the way they do.

He tries to answer questions and solve problems with the help of his classmates (May, Gerald, and Gabriela), Teacher Susie, and his family (his mother Alice, his father Mort, his Grandma Rose and his baby brother Zeke).

The fourth week (episodes 16 – 20) focuses on health (including brushing teeth, eating good-tasting food, sneezing and exercise).

won in the Children's Programming category Saturday at the 26th Genesis Awards, presented by the Humane Society of the United States.