Slaughter Run is a 5.67 mi (9.12 km) long tributary to South Branch French Creek in Erie County, Pennsylvania and is classed as a 1st order stream on the EPA waters geoviewer site.

[4] Slaughter Run rises in Wayne Township of Erie County, Pennsylvania northwest of Five Points and then flows south to meet South Branch French Creek west of Lovell, Pennsylvania.

Slaughter Run drains 5.67 square miles (14.7 km2) of Erie Drift Plain (glacial geology).

The watershed receives an average of 47.1 in/year of precipitation and has a wetness index of 452.75.

[4]