Solid-phase microextraction

[2] The quantity of analyte extracted by the fibre is proportional to its concentration in the sample as long as equilibrium is reached or, in case of short time pre-equilibrium, with help of convection or agitation.

After extraction, the SPME fiber is transferred to the injection port of separating instruments, such as a gas chromatography and mass spectrometry,[3] where desorption of the analyte takes place and analysis is carried out.

[7] In one of the study the fiber coating method significantly enhances the performance of SPME by ensuring a high binding capacity and improved mass transfer efficiency.

By preventing the ingress of the polymeric adhesive matrix into the pores of the sorbent particles, the method allows for faster adsorption and desorption times, which is crucial for high-throughput applications.

For instance, SPME has been successfully employed to detect drugs of abuse, explosives, and other volatile compounds from various samples, allowing for the efficient identification of substances relevant to criminal cases.