[3] The region is comparable in size to the combined land area of the nation state of North Macedonia.

Crop cultivation, with a focus on maize, sorghum, cotton, and cassava, as well as livestock rearing, are the main economic activities.

[8] The Meatu District is covered by zone two, which has gently sloping topography and fertile clay loamy soils towards the east.

The main economic activities are crop farming and animal husbandry, and the average annual rainfall is less than 700 mm with an irregular tendency.

The first is in the region's eastern portion and empties into Lake Eyasi, which has no outlet, after draining through the Sibit River to an internal drainage basin.

The second is in the western portion of the Region and discharges its water into Lake Victoria via the Simiyu River.

While the average amount of rainfall ranges from 600 to 900 mm, the pattern of precipitation is typically uneven and unpredictable.

Although the Simiyu Region only has one radio station, Sibuka FM, TBC, ITV, and RFA can all be reached there.

While maize, sorghum, paddy, sweet potatoes, millet, and cassava are the primary food crops.

Fishing in the rest of the region is only done for home use, with the exception of the Victoria Lake shoreline in the Busega District.

At Zanzui Dam in Maswa District, there are efforts made to increase fish productivity by breeding fingerlings, mostly for Tilapia species.

[8] Simiyu region is home to Maswa Game Reserve and has a total area of 4,210 square kilometers and is located in the Bariadi District near the Serengeti National Park's borders.

Numerous animals inhabit these reserves, such as hippos, lion, zebras, buffalo, Wild Dogs, bushbuck, impala, giraffes, and baboons.

[8] Sukuma (nyantuzu), Nyiramba, Nyaturu, and Hadzabe (Tindiga), are the major indigenous ethnic groupings.

[10]: page 2  For 2002–2012, the region's 1.8 percent average annual population growth rate was the twenty-third-highest in the country.

[10]: page 6 Simiyu Region is divided into five districts and one town council, each administered by a council:[11][7][12] Simiyu Region is home to three district hospitals, located in Maswa, Meatu, and Bariadi, as well as one designated hospital that is run by a religious institution.

There are four government vocational training centers in the region, and a total of 217 students attend them, 124 of whom are male and 93 female.