[6] Katavi Region is located between Longitude 30° and 33° East of Greenwich and Latitudes 5° 15° to 7° 03° South of the Equator.

At an altitude of 1,000 to 2,500 meters above sea level, the Katavi Region has typical yearly temperatures between 26 and 30 degrees Celsius.

The district is made up of gentle plains, plateaus, tiny mountain peaks, moderate hills, and Mwese highlands.

[8] Agriculture makes up the majority (96%) of the region's economic activity, while 0.7% of the labor force is employed in the care of livestock.

In the Katavi Region, small-scale farmers with dispersed land holdings for different crops are the main agricultural producers.

Maize, rice, sunflower, sesame, groundnuts, cassava, millet, sweet potatoes, and sorghum are some of the major crop products produced.

Additionally, there are areas designated as forest reserves, such as the ones in Inyonga, North East Mpanda, Msaginya, Mulele Hills, Rungwa, Kabungu, Ugalla River, and Rungwa River (all owned by the central government), Nkamba and Tongwe West (under local authority ownership).

With 4.7 million acres, the Mlele District Council claims to have the largest natural forest area.