He served as the chairman of Populations Communication International, a non profit advocating for a change in attitudes toward family planning.

Irwin Fox was born on June 17, 1925, to a Jewish family in the Parkville section of Brooklyn, New York, to parents Gertrude (Goldberg) and Julius A.

His life was saved by Master Sergeant Roddie Edmonds saying, "We are all Jews here" when the Nazi officers demanded that all Jewish prisoners of war be pointed out.

[4] He returned to the United States after the war and graduated with a bachelor's degree in television and radio production from New York University in 1947.

In an interview for PBS's The American Experience he described the show as "Taking two children on sort of an electronic field trip every week – live, remote location, no audience, no sponsors".

[3] Fox's version of the program was a mixture of slapstick and serious content, with the marathon Wonderama (during Fox's tenure the show ran four hours Sunday mornings) including Shakespearean dramatizations, guest celebrities including John Lindsay and Robert Kennedy, magic demonstrations (customarily by magician James "The Amazing" Randi), art instruction, spelling bees, Simon Says, learning games, or other elements.

Based upon the "color war" team competitions common at children's summer camp, participants engaged in a wide range of contests.

Guests on the program included Yogi Berra, Tim Conway, Huntz Hall, Charlotte Rae, and Soupy Sales.

Because Fox was under "exclusive" contract to WNEW-TV, On Your Mark aired on Channel 5 in New York, instead of ABC's station WABC-TV.

[4] In the mid-1980s, Fox joined and later became the chairman of the board for Population Communications International[17] (PCI), a New York-based nonprofit dedicated to improving family planning issues through popular media.