The stream passes through a small unnamed pond and turns east, entering another wetland.

The stream then reenters Forkston Township, Wyoming County and meanders north through three more wetlands.

The stream then turns north for a few tenths of a mile before reaching its confluence with Mehoopany Creek.

[1] South Brook joins Mehoopany Creek 16.94 miles (27.26 km) upstream of its mouth.

[2] The mouth of the stream is in the United States Geological Survey quadrangle of Dutch Mountain.

[7] Wild trout naturally reproduce in South Brook from its headwaters downstream to its mouth.

[9] The stream was noted to have a good wild trout population in the 1986 issue of the Pennsylvania Angler.