It crosses over the Pacolet River on an unnamed bridge, where it enters Cherokee County.

In the southern part of Gaffney, the highway begins a concurrency with SC 18 (Frederick Street) near Limestone College.

It turns left onto Union Street, and follows that road until it meets College Drive.

After a temporary departure from the city limits, where the highway passes a Freightliner plant, it meets its northern terminus, an interchange with Interstate 85.

In 1939, its northern terminus was extended through Gaffney to the North Carolina state line north-northwest of the city.

It curves to the southeast and reaches its eastern terminus, an intersection with the SC 105 mainline.

It is located in a rural portion of Cherokee County, at a point south-southeast of Draytonville.