South Carolina Highway 329 (SC 329) is a 6.350-mile (10.219 km) primary state highway in the U.S. state of South Carolina.

It serves as an eastern bypass to the town of Gaffney.

In 1948, it was decommissioned and downgraded to secondary roads S-36-28 and S-40-32.

South Carolina Highway 180 (SC 180) was established as a new primary routing between U.S. Route 29 (US 29) and SC 18 northeast of Gaffney.

The entire route is in Cherokee County.