South Carolina Highway 122 (SC 122), also known as Dave Lyle Boulevard, is a 5.740-mile (9.238 km) state highway in Rock Hill, York County, South Carolina.

From there, it follows Dave Lyle Boulevard northeasterly, intersecting Main Street and further down a full interchange with U.S. Route 21 (US 21)/SC 121.

The highway continues on a more easterly course to an interchange with Interstate 77 (I-77) before terminating at Waterford Park Drive.

In 2001, it was extended to its current eastern terminus at Waterford Park Drive.

Future plans are to construct an extension of SC 122 east into Lancaster County, ending at the US 521/SC 75 intersection; which will connect the Catawba Reservation and provide another crossing over the Catawba River.