South Carolina Highway 75 (SC 75) is an 8.110-mile (13.052 km) state highway in the U.S. state of South Carolina.

Heading east, SC 75 passes the AME Zion Church and Van Wyck's farmland as well as the "downtown" of the tiny community.

Two miles to the east, SC 75 intersects US 521 and is concurrent with the highway until they split three miles to the north in the unincorporated community of Hancock.

[2] Established in 1937 as a renumbering of SC 12, it originally ran from US 521 to the North Carolina state line in Hancock.

[3][unreliable source] The entire route is in Lancaster County.